52
The Dream of Elixir Vitae
CELL THERAPY
Gene therapy and RNAi are limited in the number of genes
they can affect in cells. One way to overcome this limitation
is by replacing the cells themselves, a process known as cell
therapy. Since there are few theoretical restrictions as to the
number of genetic modifications cells can endure, cell ther-
apy has a greater bandwidth. For example, in an experiment
aimed at treating the immunodeficiency disease SCID-X1,
cells from the immune system were extracted from a patient,
genetically engineered, and inserted back again with encour-
aging results. [19]
One growing area involves stem cells. A stem cell is a sort
of unprogrammed cell that has the potential to become
any type of cell in the adult body. Aging has been linked
to an age-related inability of stem cells to replenish mature
cells and so therapeutic interventions that enhance stem cell
functional capacity might ameliorate the age-associated atro-
phies of several organ systems. [20] More importantly, with
nuclear transfer experiments such as Dolly [3], it is now pos-
sible to turn back the clock and generate embryonic stem
cells from an adult. [21;22] In theory, it is possible to geneti-
cally modify these cells according to needs, differentiate them
into the necessary tissue or organ and then implant them to
treat age-related diseases, a procedure called therapeutic clon-
ing. [23;24] Since these cells are genetically identical to the
patients there are few or no problems of immune rejection.
The ability of stem cells to regenerate virtually all types of
tissues holds great promise. [25] In theory, it is possible to
create practically all components of a human being in the lab
and then replace the patients organs and tissues one by one.
Stem cells have been used with success against heart disease,
[26] or to repair damage to the brain [27] and spinal cord.
[28] Also, stem cells are incredibly versatile: transplantation of